Publications

2019

Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, Bourboulia D, Mollapour M. Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity. Oncotarget. 2019;10(56):5824-34.

Baker-Williams AJ, Hashmi F, Budzyński MA, Woodford MR, Gleicher S, Himanen SV, Makedon AM, Friedman D, Cortes S, Namek S, Stetler-Stevenson WG, Bratslavsky G, Bah A, Mollapour M, Sistonen L, Bourboulia D. (2019). Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis. Cell Reports. 13;28(7):1894-1906,

Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. (2019). Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90. Cell Reports. 26(5):1344-1356.

 

Blair, L.J., Genest, O., and Mollapour, M. (2019). The multiple facets of the Hsp90 machine. Nat Struct Mol Biol. 26(2):92-95.

 

2018

Daugherty, M., Daugherty, E., Jacob, J., Shapiro, O., Mollapour, M., and Bratslavsky, G. (2018). Renal cell carcinoma and brain metastasis: Questioning the dogma of role for cytoreductive nephrectomy. Urologic Oncology. S1078-1439(18)30405-8.

Sager RA, Woodford MR, Mollapour M, (2018). The mTOR Independent Function of Tsc1 and FNIPs. Trends in biochemical sciences. 43(12):935-937.

 

Sager RA, Woodford MR, Shapiro O, Mollapour M, Bratslavsky G, (2018). Sporadic renal angiomyolipoma in a patient with Birt-Hogg-Dubé: chaperones in pathogenesis. Oncotarget. 2018. 24;9(31):22220-22229.

Sánchez-Pozo J, Baker-Williams AJ, Woodford MR, Bullard R, Wei B, Mollapour M, Stetler-Stevenson WG, Bratslavsky G, Bourboulia D, (2018). Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity. iScience. 1:87-96.

Cortes S, Baker-Williams AJ, Mollapour M, Bourboulia D, (2018). Detection and Analysis of Extracellular Hsp90 (eHsp90). In “Molecular Chaperones: From Folding Quality to Physiological Function”, (Eds. Prince T. and Calderwood SK). Methods in Molecular Biology, Humana: London. 1709:321-9.

Sager, RA, Woodford, MR, Neckers L, and Mollapour M, (2018). Detecting post-translational modifications of Hsp90. In “Molecular Chaperones: From Folding Quality to Physiological Function”, (Eds. Prince T. and Calderwood SK). Methods in Molecular Biology, Humana: London. 1709:209-19.

2017

Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M, (2017). Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer. Cell Rep. 21: 1883-1895.

 

Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M, (2017). Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. EMBO J. 15;36(24):3650-3665.

2016

Oberoi J, Dunn DM, Woodford MR, Mariotti L, Schulman J, Bourboulia D, Mollapour M, Vaughan CK. (2016). Structural and functional basis of protein phosphatase 5 substrate specificity. Proc Natl Acad Sci U S A. 113;32:9009-9014.

Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M, (2016). The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nat Commun.  29;7:12037-12052.

Woodford MR, Dunn DM, Ciciarelli JG, Beebe K, Neckers L, Mollapour M, (2016). Targeting Hsp90 in Non-Cancerous Maladies. Curr Top Med Chem. (13). 265-277.

Bratslavsky G, Woodford MR, Daneshvar M, Mollapour M, (2016). Sixth BHD symposium and first international upstate kidney cancer symposium: latest scientific and clinical discoveries. Oncotarget. (10): 733-36.

Woodford MR, Truman AW, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, Trepel JB, Landas S, Prodromou C, Shapiro O, Stetler-Stevenson WG, Bourboulia D, Neckers L, Bratslavsky G, Mollapour M, (2016). Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Cell Rep. (4):872-84.

Woodford MR, Dunn D, Miller JB, Jamal S, Neckers L, Mollapour M, (2016). Impact of Posttranslational Modifications on the Anticancer Activity of Hsp90 Inhibitors. Adv Cancer Res. 129:31-50.

2015

Wolfgeher D, Dunn DM, Woodford MR, Bourboulia D, Bratslavsky G, Mollapour M, Kron SJ, Truman AW, (2015). The dynamic interactome of human Aha1 upon Y223 phosphorylation. Data Brief. 5:752-5.

Daugherty M, Blakely S, Shapiro O, Vourganti S, Mollapour M, Bratslavsky G, (2015).  Chromophobe Renal Cell Carcinoma is the Most Common Nonclear Renal Cell Carcinoma in Young Women: Results from the SEER Database. J Urol. 10:5347-53

 

Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M, (2015). c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell Rep. 6:1006-18

Chehab M, Caza T, Skotnicki K, Landas S, Bratslavsky G, Mollapour M, Bourboulia D, (2015). Targeting Hsp90 in urothelial carcinoma. Oncotarget. 11:8454-73.

 

Neckers L, and Mollapour M, (2015). Chapter 56: Heat Shock Protein 90 and the Proteasome: Housekeeping Proteins that are also Molecular Targets for Cancer Therapy. In J. Mendelsohn, J. W. Gray, P. M. Howley, M. A. Israel, and C. B. Thompson (Eds.) The Molecular Basis of Cancer. 4th ed. Elsevier Inc. 56:779-788

 

2014

Mollapour M†, Bourboulia D, Beebe K, Woodford M R, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee M J, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson W G, Bratslavsky G, Trepel J B, Prodromou C and Neckers L. (2014). Asymmetric HSP90 N-domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Mol Cell. 53(2):317-29. †Co-Corresponding author.

 

Woodford M R, Madala A, Schulman J, Nsouli T and Mollapour M, (2015). Efficacy of Hsp90 inhibitors in prostate cancer. Journal of Urology and Nephrology. 2014; 1(1):9-13.

 

 

2013

Miyajima N, Tsutsumi S, Sourbier C, Beebe K, Mollapour M, Rivas C, Yoshida S, Trepel JB, Huang Y, Tatokoro M, Shinohara N, Nonomura K, and  Neckers L, (2013). The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and crizotinib-resistant MET-driven tumor models. Cancer Res. 73(23):7022-33.

Walton-Diaz, A., Khan, S., Mollapour, M., and Neckers, L, (2013). Targeted Therapies in Oncology. Second Edition ed. Giaccone, G, Soria J, (Eds). New York: CRC-Informa Healthcare. Chapter 10, The Cancer Super-Chaperone Hsp90: Its Posttranslational Regulation and Drug Targeting; 234-246.

 

Walton-Diaz, A., Khan, S., Trepel J.B., Mollapour, M., and Neckers, L, (2013). Inhibitors of Molecular Chaperones as Therapeutic Agents. Machajewski TD, Gao Z, (Eds). London: The Royal Society of Chemistry; Chapter 12, The Cancer Super-Chaperone Hsp90: Its Posttranslational Regulation and Drug Targeting; 318-335

 

Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L and Mollapour M, (2013) Contributions of Post-translational Modifications and Co-chaperones towards Hsp90 Drug Sensitivity. Future Medicinal Chemistry. 5(9):1059-71.

 

Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L, (2013). Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors. Oncotarget. 4(7):1065-74.

 

2012

Alarcon SV, Mollapour M, Lee MJ, Tsutsumi S, Lee S, Kim YS, Prince T, Apolo A, Giaccone G, Xu W, Neckers LM, Trepel JB, (2012). Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90-Targeted Therapy. Curr Mol Med. 12, 1125-1141.

 

Iwai A, Bourboulia D, Mollapour* M, Jensen-Taubman S, Lee S, Donnelly AC, Yoshida S, Miyajima N, Tsutsumi S, Smith AK, Sun D, Wu X, Blagg BS, Trepel JB, Stetler-Stevenson WG, Neckers L, (2012). Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells. Cell Cycle. 11(19):3649-55. * Joint first author.

 

Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A, Trepel J, Miyata Y, Matts R, and Neckers L, (2012). Dynamic tyrosine phosphorylation modulates cycling of the Hsp90-Cdc37-Aha chaperone machines. Mol. Cell. 10;47(3):434-43.

Tsutsumi S, Mollapour M*, Prodromou C, Lee C, Panaretou B, Yoshida S, Mayer MP, and Neckers L, (2012). Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. PNAS. 109(8):2937-42. * Joint first author.

 

Mollapour M, and Piper PW, (2012). Activity of the yeast zinc-finger transcription factor War1 is lost with alanine mutation of two putative phosphorylation sites in the activation domain. Yeast. 29(1):39-44.

 

Mollapour M†, and Neckers L, (2012). Detecting Hsp90 phopshorylation. In “Molecular Chaperones: From Folding Quality to Physiological Function”, (eds. Prince T. and Calderwood SK). Methods in Molecular Biology, Humana: London, 787:67-74. †Corresponding author.

 

Mollapour M†, and Neckers L, (2012). Post-translational modifications of Hsp90 and their contributions to chaperone regulation. Biochim Biophys Acta. 1823(3):648-55. †Corresponding author.

 

2011

Mollapour M†, Tsutsumi S, Kim YS, Trepel J and Neckers L, (2011). Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity. Oncotarget. 2(5):407-17. †Corresponding author.

 

Mollapour M, Tsutsumi S, Truman AW, Xu W, Vaughan CK, Beebe K, Konstantinova  A, Vourganti S, Panaretou B, Piper PW, Trepel JB, Prodromou C, Pearl LH, Neckers L, (2011) Threonine 22 phosphorylation attenuates Hsp90 interaction with co-chaperones and affects its chaperone activity. Mol. Cell. 18;41(6):672-81.

Selected as a research highlight, Mol Cell. 18;41(6):619-20.

Selected by Faculty of 1000 Biology

 

Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS (2011). A systematic protocol for the characterization of Hsp90 modulators. Bioorg Med Chem. 19(1):684-92).

 

2010

Trepel JB, Mollapour M, Giaccone G, Neckers L, (2010). Targeting the dynamic Hsp90 complex in cancer. Nat. Rev. Cancer. 10(8):537-49. (Review)

 

Mollapour M, Tsutsumi S, Neckers L, (2010). Hsp90 phosphorylation, Wee1, and the cell cycle. Cell Cycle. 9(12): 1-7.

 

Mollapour M, Tsutsumi S, Donnelly AC, Beebe K, Tokita MJ, Lee MJ, Lee S, Morra G, Bourboulia D, Scroggins BT, Colombo G, Blagg BS, Panaretou B, Stetler-Stevenson WG, Trepel JB, Piper PW, Prodromou C, Pearl LH, Neckers L, (2010). Swe1/Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol. Cell. 37(3):333-43.

Selected as a research highlight, Mol Cell. 12;37(3):295-6.

 

Mollapour M, Neckers L, (2010). Quinacrine: New anti-tumor application for an old anti-malaria drug. Cell Cycle. 15;9(2):228.

 

2009

Tsutsumi S*, Mollapour M*, Graf C, Lee CT, Scroggins BT, Xu W, Haslerova L, Hessling M, Konstantinova AA, Trepel JB, Panaretou B, Buchner J, Mayer MP, Prodromou C, Neckers L, (2009). A short beta strand in the N-domain cooperates with the adjacent charged linker to regulate Hsp90 function. Nat. Struct. Mol. Biol. 16(11):1141-7. * Joint first author.

Mollapour M, Shepherd A and Piper PW, (2009). Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses the Slt2(Mpk1)p activation, with acetic acid stress of yeast. Microbiology. 155(10):3304-11.

 

Sudarshan S, Sourbier C, Kong H, Block K, Valera V, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L. (2009). Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and HIF1-a stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol. 29(15):4080-90.

 

Neckers, L, Mollapour M, and Tsutsumi S, (2009). The complex dance of the molecular chaperone Hsp90. Trends. Biochem. Sci. 34(5):223-6.

 

Neckers, L, Tsutsumi S, and Mollapour M, (2009). Visualizing the twists and turns of a molecular chaperone. Nat. Struct. Mol. Biol. 16(3):235-6

 

Millson SH, Nuttall JM, Mollapour M, Piper PW. The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae. Yeast. 2009. 26(6):339-347.

2008

Vaughan CK*, Mollapour M*, Smith J, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke P, Workman P, Piper PW, Prodromou C and Pearl LH, (2008). Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell. 31(6):886-895. *Joint first author.

Mollapour M, Shepherd A and Piper PW, (2008). Novel stress responses facilitate Saccharomyces cerevisiae growth in the presence of the monocarboxylate preservatives. Yeast. 25(3):169-77. (Review)

Mollapour M. and Piper PW, (2008). Weak acid resistance of spoilage yeasts. In “Stress in Yeast and Filamentous Fungi” (eds. Avery S. and van West P). British Mycology Society. Chapter 10. 143-155. (Book Chapter)

 

2007

Mollapour M, and Piper PW, (2007). Hog1 MAP kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid. Mol Cell Biol. 27(18):6446-56.

Selected by Faculty of 1000 Biology.

 

Millson SH, Truman AW, Racz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Soti C, Piper PW, (2007). Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol. FEBS J. 274(17):4453-63.

 

Truman AW, Millson SH, Nuttall JM, Mollapour M, Prodromou C and Piper PW, (2007). In the yeast heat shock response Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2(Mpk1) MAP kinase. Eukaryot Cell. 6(4):744-52.

2006

Mollapour M. and Piper PW, (2006). Hog1 MAP kinase determines acetic acid resistance in Saccharomyces cerevisiae. FEMS Yeast Research. 6(8):1274-80.

 

Truman AW, Millson SH, Nuttall JM, King V, Mollapour M, Prodromou C, Pearl LH and Piper PW., (2006). Expressed in yeast, human ERK5 is a client of the Hsp90 chaperone and complements loss of the Slt2(Mpk1)p cell integrity stress-activated protein kinase. Eukaryot Cell.

5(11):1914-24

 

Mollapour M, Phelan JP, Millson SH, Piper PW and Cooke FT., (2006). Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae. Biochem. J. 395(1):73-80

 

2005

Hu B, Liao C, Millson S, Mollapour M, Prodromou C, Pearl L, Piper PW and Panaretou B, (2005). Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Mol. Microbiol. 55(6)1735-50.

 

Harris N, Bachler M, Costa V, Mollapour M, Moradas-Ferreira P and Piper PW, (2005). Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase. Aging Cell. 4(1):41-52.

 

2004

Mollapour M, Fong D, Balakrishnan K, Harris N, Thompson S, Schüller C, Kuchler K and Piper PW, (2004). Screening the yeast deletant mutant collection for hypersensitivity and hyperresistance to sorbate, a weak organic acid food preservative. Yeast 21:927-946.

 

Schüller C, Mamnun YM, Mollapour M, Krapf G, Schuster M, Bauer BE, Piper PW and Kuchler K., (2004). Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Mol Biol Cell.15(2):706-20.

 

2003

Piper PW, Millson SH, Mollapour M, Panaretou B, Siligardi G, Pearl LH and Prodromou C, (2003). Sensitivity to Hsp90-targetting drugs can arise with mutation to the Hsp90 chaperone, co-chaperones and plasma membrane ATP binding cassette transporters of yeast. Eur J Biochem. 270(15):4689-95.

Mollapour M*, Bauer BE*, Rossington D*, Mamnun Y, Kuchler K and Piper PW., (2003). Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants. Eur J Biochem. 270(15):3189-95. *Joint first author.

 

Kren A, Mamnun YM, Bauer BE, Schüller C, Wolfger H, Hatzixanthis K, Mollapour M, Gregori C, Piper PW and Kuchler K., (2003) War1p, a novel transcription factor controlling weak acid stress response in yeast. Mol Cell Biol. 23(5):1775-85.

 

Hatzixanthis K, Mollapour M, Seymour I, Bauer BE, Krapf G, Schüller C, Kuchler K and Piper PW, (2003). Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP-binding cassette transporter. Yeast. 20(7):575-85.

 

Piper PW, Panaretou B, Millson SH, Trumana A, Mollapour M, Pearl LH and Prodromou C., (2003). Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene. 302(1-2):165-70.

 

Harris N, Costa V, MacLean M, Mollapour M, Moradas-Ferreira P and Piper PW, (2003). Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells. Free Radic. Biol Med. 15;34(12):1599-606.

2002

Piper PW, Jones GW, Bringloe D, Harris N, MacLean M and Mollapour M. (2002). The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cell. Aging Cell. 1(2):149-57.

 

Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman, P, Piper PW, Pearl LH and Prodromou C, (2002). Activation of the ATPase activity of Hsp90 by the stress-regulated co-chaperone aha1. Mol Cell.10(6):1307-18.

 

2001

Piper P, Calderon CO, Hatzixanthis K and Mollapour M, (2001). Weak acid adaptation: the stress response that confers yeasts with resistance to organic acid food preservatives. Microbiology. 147:2635-42. (Review)

 

Mollapour M, and Piper PW, (2001). The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in S. cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives. Mol Microbiol. 42(4):919-30.

 Mollapour M, and Piper PW, (2001). Targeted gene deletion in Z. bailii. Yeast. 30;18(2):173-86. 

mollapom@upstate.edu

(315)464-8749

Departments of Urology &

Biochemistry and Molecular Biology

Upstate Medical Univeristy

766 Irving Ave

Syracuse, NY 13210